History of Preimplantation

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History of Preimplantation Genetic Diagnosis in Spain since 1990 published the first cases of children born after preimplantation genetic diagnosis (PGD), the European Society for Human Reproduction and Embryology (ESHRE) through their consortium has DGP results compiled annually and 12,397 cycles developments that led to 2027 newborns through October 2005. The first compilation of data from this group included a total of 392 PGD cycles performed until September 1998 and the latest publication includes a total of 3358 PGD cycles performed only during 2004 in 45 affiliated centers, which shows the increase in the number of couples who undergo such treatment. Nationally, the Department of Cell Biology at the Autonomous University of Barcelona was a pioneer in this field, particularly in cytogenetic studies using FISH.The first publication of a pregnancy achieved in Spain by DGP was conducted jointly by this group and the Dexeus Institute in 1994 in a couple where the woman was a carrier of hemophilia. In 2001, Jimenez Diaz Foundation Dr. Alfonso de la Fuente and Dr. Esther Fernandez (currently Director of Preimplantation Genetic Diagnosis Geniality) achieved the first birth of a child, child of a parent with Huntington’s chorea, free of genetic inheritance that would develop the disease in the future. The application of this technique has spread to other centers in various autonomous communities.Finally progress in molecular genetics in the characterization of specific mutations in a large number of monogenic diseases, given the chance to go adding to the list of those diseases diagnosable by PGD diseases such as Cystic Fibrosis first performed by the group at the UAM in collaboration with the IVI and the emergence of other diagnostic centers in Barcelona and in Valencia. In 2009 it developed a new technique of preimplantation genetic diagnosis using microchips, called aCGH (array CGH)

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